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Lipid Treatment in Diabetic Patients: from Guidelines to Clinical Practice

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A17015FKA17015FKArtikel JurnalPerpustakaan FKUITersedia

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Morbidity and mortality rate arising from atherosclerotic cardiovascular disease
(ASCVD) in diabetic patients, in developing or even in develop countries are still
high. There was study conducted at the Joslin Clinic, -the Diabetes Natural
History Study-, followed for up to 25 years patients diagnosed between 1939 and
1959. Among men diagnosed between ages 30 and 49 years, there was no excess
mortality until after age 50 years, in contrast with women, who had significant
excess mortality from age 30 years and on. The median survival age was 66 years
for men and 65 years for women, respectively, 5 and 12 years shorter than in the
general population. Patients diagnosed between ages 50 and 69 years could
expect median survival of 71 and 72 years, respectively -2 and 5 years shorter
than the general population.1
A question then comes out: “Why do people with diabetes die too soon?” The
common conditions coexisting with type 2 diabetes mellitus (T2DM) such as
hypertension and dyslipidemia are clear risk factors for ASCVD, and diabetes
itself confers independent risk. Many studies have shown the efficacy of
controlling individual cardiovascular risk factors in preventing or slowing the
progression of ASCVD in people with diabetes. There are large benefits seen
when multiple risk factors are addressed simultaneously. Type 2 diabetes
patients have an increased prevalence of dyslipidemia, contributing to their high
risk of ASCVD.2
This paper will focus on the management of one part of ASCVD risk factors that is
dyslipidemia in diabetes.

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